Giant condyloma acuminatum (GCA) commonly known as Buschke-Lowenstein tumor (BLT) is a rare sexually transmitted disease, which is always preceded by condyloma accuminata and linked to human papillomavirus (HPV). Most commonly affected sites are male and female genitalia, anal and perianal regions. Giant condyloma acuminatum is well-known as slow growing but locally destructive with a high rate of recurrence and increased frequency of malignant transformation. Surgical management is considered to be the best among all the options.

Introduction: Giant condyloma of the cervix (GCC) is an uncommon entity that has been poorly characterized in the literature, being even more uncommon during the pregnancy.Case Presentation: The authors describe a case of GCC in a pregnant woman as well as reviewing the literature on the topic aiming to reach a better understanding of the natural history of this entity. Our patient is a 27-year-old primigravida of Asian origin. The patient has been diagnosed with cervical giant condyloma in a second trimester coitorrhage context.Conclusion: A conservative treatment of the giant condyloma could be preferable during pregnancy, carrying surgical excision out after birth.

Buschke-Lowenstein Tumor (BLT) or Giant Condyloma Acuminatum (GCA) is a slow-growing, locally aggressive, cauliflower-like tumor of great size that usually arises in the perineal region. Buschke-Lowenstein Tumor is triggered by human papilloma virus (HPV), usually either genotype 6 or 11. Buschke-Lowenstein Tumor is usually preceded by condyloma acuminatum and occurs at any age after puberty, usually between the 4th and 6th decades. Invasive overgrowth and recurrence after treatment are its characteristics and malignant transformation is also possible. Here, we have reported a case of a 33 year-old man with penile Buschke-Lowenstein Tumor arising from common genital warts.

Individuals with Selective Immunoglobulin-A Deficiency (SIgAD) are often asymptomatic, and symptomatic SIgAD patients often have autoimmune comorbidities. A 48-year-old Han Chinese man presented with abdominal discomfort, hematochezia, and a large tumor in the anogenital region. The primary diagnosis of SIgAD was based on the patient’, s age, serum IgA concentration (0. 067 g/L), and the evidence of chronic respiratory infection. No other immunoglobulin deficiency or evidence of immunosuppression was present. The primary diagnosis of giant condyloma acuminatum was based on human papilloma virus-6-positive laboratory results and histological characteristics. The tumor and adjacent skin lesions were resected. Hemoglobin concentration fell to 5. 50 g/ dL, and an emergency erythrocyte transfusion was performed. The body temperature increased to 39. 8 º, C, suggesting a transfusion reaction, and 5 mg dexamethasone was administered intravenously. Hemoglobin concentration stabilized at 10. 5 g/dL. The clinical signs and laboratory results indicated autoimmune hemolytic anemia, systemic lupus erythematosus, and Hashimoto’, s thyroiditis. Abdominal discomfort and hematochezia subsided. Though un-common, the manifestation of multiple autoimmune comorbidities can occur in SIgAD patients. Further research is needed regarding the causes of SIgAD and the autoimmune disorders that often occur as comorbidities.